IMMUNE-MEDIATED NECROTIZING MYOPATHY: AN IMPORTANT DIFFERENTIAL DIAGNOSIS OF MUSCLE WEAKNESS
Miopatia necrotizante imunomediada (IMNM) é um tipo de miopatia autoimune caracterizada por fraqueza proximal relativamente grave, enzimas musculares elevadas (creatina quinase, CPK,> 10.000), presença de anticorpos específicos e pouco ou nenhum infiltrado inflamatório na biópsia muscular, geralmente associada ao uso de estatinas. A revisão da literatura sugere a frequência em torno de 2 ou 3 casos a cada 100.000 pacientes.
IMMUNE-MEDIATED NECROTIZING MYOPATHY: AN IMPORTANT DIFFERENTIAL DIAGNOSIS OF MUSCLE WEAKNESS
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DOI: 10.22533/at.ed.1592107128
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Palavras-chave: Miopatia necrotizante imunomediada, estatinas, imunoglobulina intravenosa (IVIG)
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Keywords: Immune-mediated necrotizing myopathy, statins, intravenous immunoglobulin (IVIG)
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Abstract:
Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune myopathy characterized by relatively severe proximal weakness, elevated muscle enzymes (creatine kinase, CPK, > 10.000), presence of specific antibodies and little or none inflammatory infiltrate on muscle biopsy, usually associated to the use of statins. Literature review suggests the frequency around 2 or 3 cases in each 100.000 patients.
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Número de páginas: 2
- Dayani Regina de Barros Freitas
- Nelson Araujo Silva Filho
- Carla Oliveira Monteiro da Silva
- Carolina Arribada Rebello
- Camila Aguiar Lomônaco
