Hepatic and renal function of mares submitted to bothrops antigen inoculation for production of antiophidian serum

• DOI: 10.22533/at.ed.159342318018

• Palavras-chave: Equines, antiophidian serum, liver, kidney, Bothrops.

• Keywords: Equines, antiophidian serum, liver, kidney, Bothrops.

• Abstract:

  Snakebites have been a medical and veterinary challenge. The only treatment available and recommended by the World Health Organization and the Ministry of Health is serum therapy. The objective of the study was to evaluate the liver and kidney function of horses submitted to the basic immunization protocol currently used by Instituto Vital Brazil for the production of antibothropic serum. 05 horses were evaluated with bothrops venom inoculation during the period of three immunization cycles. Blood samples were collected for biochemical examination and liver and kidney evaluation, which is essential to increase knowledge about these poison inoculation protocols to cause liver damage. The ALT, albumin and creatinine parameters had no effect (p>0.05) of time. The variables AST, GGT, total proteins and globulin showed higher values (p<0.05) in T3 compared to T1 and T2. Urea showed a higher value at T1. There was a trend (p=0.07) of AF elevation at T3. The results obtained suggest that over the period of baseline immunization, liver changes may occur, but not kidneys.