BIOFILM FORMATION AND ANTIFUNGAL SENSITIVITY OF Candida albicans, Candida tropicalis, Candida glabrata E Candida auris

• DOI: https://doi.org/10.22533/at.ed.1594132423017

• Palavras-chave: Candidiasis, Candida spp., antifúngicos, biopelículas.

• Keywords: Candidiasis, Candida spp., antifungals, biofilms.

• Abstract:

  In recent years, the incidence of opportunistic fungi has increased significantly, with candidiasis being the most common mycosis. Recently, non-albicans Candida species increased considerably, being more frequent than Candida albicans, the species: Candida tropicalis, Candida glabrata, Candida dubliniensis, Candida auris among others, which can cause anything from a superficial infection to a systemic infection; However, currently: C. albicans seems to have regained dominance as the etiological agent of this opportunistic mycosis. On the other hand, the increase in strains resistant to antifungals has become a public health problem, with fatal consequences for the patient. Candidiasis can represent a significant burden of infections in the hospital population because this mycosis is associated with the formation of biofilms, these constitute layers of the microorganism adhered to biotic or abiotic surfaces that complicate the access of drugs and thus its elimination, becoming a focus of dissemination of the infection, increasing hospital stay and, therefore, care costs and mortality. In this chapter we will describe the formation of biofilms and sensitivity to antifungals using as a model: C. albicans, C. tropicalis, C. glabrata and C. auris.