Factors associated with death from COVID-19 in multimorbid patients

• DOI: 10.22533/at.ed.1593602316081

• Palavras-chave: Coronavirus; COVID-19; Intensive Care; Chronic diseases; Multimorbidity.

• Keywords: Coronavirus; COVID-19; Intensive Care; Chronic diseases; Multimorbidity.

• Abstract:

  Multimorbid patients are a group at high risk of death and the factors associated with death from COVID-19 in these patients are still poorly understood. The aim of the present retrospective cohort study was to identify predictors of death from COVID-19 in multimorbid patients with SARS-CoV-2 infection confirmed by RT-PCR admitted to Brazilian hospitals. Sociodemographic, clinical and hospital characteristics of 3460 patients notified in the National COVID-19 Surveillance were analyzed using a multivariable logistic regression model. Age over 45 years, non-white race/color, respiratory distress, increasing number of chronic diseases, ICU admission and invasive mechanical ventilation increased the risk of death between 1.19 and 9.8 times. On the other hand, asthma, heart disease, diabetes and obesity reduced the risk of death between 0.45 and 0.71 times. Contrary to expectations, chronic lung and kidney diseases were not predictors of death.
  More prospective studies must be carried out considering the combinations of chronic diseases and the effects on death from COVID-19.