EXPRESSION OF CIRCULATING miR-7-5P microRNA AND ITS RELATIONSHIP WITH GLYCEMIC BIOMARKERS IN WOMEN WITH METABOLIC SYNDROME

• DOI: 10.22533/at.ed.1592472215081

• Palavras-chave: Diabetes Mellitus, microRNA; Nutrigenomics; Metabolic syndrome

• Keywords: Diabetes Mellitus, microRNA; Nutrigenomics; Metabolic syndrome

• Abstract:

  Inflammation and oxidative stress are processes that occur simultaneously in the metabolic syndrome, contributing to the increase in the synthesis of inflammatory mediators. Some micronutrients, such as manganese, have anti-inflammatory properties, being important to reduce the risk of chronic diseases, such as diabetes mellitus, associated with the inflammatory state observed in metabolic syndrome. The investigation of possible molecular mechanisms, such as miR-7-5p microRNA expression, may provide more specific answers about the involvement of this miR in these pathways. Thus, this work aims to evaluate the expression of circulating miR-7-5p microRNA and its relationship with glycemic biomarkers in women with metabolic syndrome. This is a cross-sectional study with women aged between 18 and 60 years and BMI ≥ 25, who were classified with or without metabolic syndrome. The levels of miR-7-5p were evaluated to assess its expression in different metabolic situations. As a result, it was found that miR-7-5p had a positive correlation with HOMA-IR and Blood glucose (mg/dL). Thus, this work had the potential to investigate the relationship between miR-7-5p and possible epigenetic mechanisms involved in diabetes mellitus and metabolic syndrome.

• Número de páginas: 26