EXPLORING THE EFFECTS OF POLYUNSATURATED FATTY ACIDS ON LIPID METABOLISM AND RENAL FUNCTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE: A NARRATIVE LITERATURE REVIEW

• DOI: 10.22533/at.ed.813362304075

• Palavras-chave: Omega 3 fatty acids; Chronic Kidney Disease; Renal Function; Lipid Management.

• Keywords: Omega 3 fatty acids; Chronic Kidney Disease; Renal Function; Lipid Management.

• Abstract:

  Objective: To investigate the effects of omega-3 polyunsaturated fatty acids on lipid metabolism and renal function in patients with chronic kidney disease. Methodology: Narrative review of experimental and observational studies, using the Pubmed database and descriptors omega 3 fatty acids, chronic kidney disease, kidney function and lipid management, in the period from 2013 to 2023. A total of 70 articles were identified and, after applying the inclusion and exclusion criteria, 15 studies were selected for analysis. Results: Depletion of omega-3 fatty acid levels in patients with chronic renal failure has been suggested as a possible cause of an inflammatory state. Therefore, the hypothesis of n-3 PUFA supplementation emerged as a potential strategy to mitigate inflammation in individuals with CKD. Thus, polyunsaturated fatty acids have been recommended with the aim of intervening in the progression of chronic renal failure. Final considerations: The correlation between polyunsaturated fatty acids, particularly omega-3, and the positive impact on lipid metabolism and kidney function in patients with chronic kidney disease is well established.