EXPLORING THE THERAPEUTIC POTENTIALS FOR DIABETIC RETINOPATHY: A COMPREHENSIVE REVIEW

• DOI: https://doi.org/10.22533/at.ed.15945124050610

• Palavras-chave: Diabetic retinopathy, oxidative stress, NADPH oxidase, polyphenols, stem cell therapy, neuroinflammation, early intervention.

• Keywords: Diabetic retinopathy, oxidative stress, NADPH oxidase, polyphenols, stem cell therapy, neuroinflammation, early intervention.

• Abstract:

  This integrative review aims to summarize recent advances in therapeutic approaches for diabetic retinopathy. A comprehensive literature search was performed in PubMed, covering publications from 2018 to 2024. Of the 167 articles initially identified, 7 were selected for final analysis. The selected articles highlighted promising therapeutic strategies: 1) Inhibition of NADPH oxidase (NOX), with NOX inhibitors showing potential in reducing oxidative stress and vascular damage; 2) Dietary polyphenols, which modulate oxidative and inflammatory pathways, suggesting their potential as preventive and therapeutic agents; 3) Stem cell therapies, indicating that stromal/mesenchymal cells can promote neurovascular repair in the diabetic retina. This review highlights the emerging therapeutic potential of addressing oxidative stress and neuroinflammation in DR, supporting further clinical investigations into NOX inhibitors, dietary polyphenols, and stem cell therapies.