Exploring the Connection Between H. Pylori Infection and Dementia Risk: An Updated Review

• DOI: https://doi.org/10.22533/at.ed.1594592426066

• Palavras-chave: Helicobacter Pylori, Campylobacter pylori, Dementia.

• Keywords: Helicobacter Pylori, Campylobacter pylori, Dementia.

• Abstract:

  Objective: Explore the possible relationship between Helicobacter pylori infection and the risk of developing dementia, analyzing potential mechanisms and implications for prevention and management. Methodology: Bibliographic review that used the electronic database PubMed. Search terms included “Helicobacter Pylori”, “H. pylori”, “Campylobacter pylori”, “Dementia” through the following search strategy: (“Helicobacter pylori” OR “H. pylori” OR “Campylobacter pylori”) AND (Dementia). In the initial search 113 articles were found, however a total of 16 articles were selected for analysis in this review. Revision: The results reveal a significant correlation between the serointensity of H. pylori infection of specific strains and the risk of dementia, evidenced by the formation of pathogenic markers of Alzheimer's disease, malabsorptive syndrome, factors that are even more potentiated if co-infection with periodontal pathogens occurs. Final considerations: Therefore, the need for early detection of infectious risk factors in the prevention of dementia is highlighted. However, it is of fundamental importance to recognize the complexity of the topic and the need for more research to elucidate gaps in the pathophysiological mechanisms in which H. pylori can influence the development of dementia and thus, establish better prevention strategies in the population.