EXPERIMENTAL DESIGN APPLIED TO AN EXTRACTIVE SPECTROPHOTOMETRIC DETERMINATION OF DICLOFENAC
A sensitive extractive-spectrophotometric method was developed for the determination of diclofenac. To obtain the optimal extractive-spectrophotometric response for diclofenac, two statistical models were applied: the Box-Behnken experimental design model and the response surface plot. Good agreement with Beer's law was found within the diclofenac concentration range of 0.2-2.0 µg/ml, with a detection limit of 0.02 µg/ml. The method was successfully applied to the determination of diclofenac in various pharmaceutical formulations, yielding satisfactory results.
EXPERIMENTAL DESIGN APPLIED TO AN EXTRACTIVE SPECTROPHOTOMETRIC DETERMINATION OF DICLOFENAC
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DOI: https://doi.org/10.22533/at.ed.317542517033
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Palavras-chave: Diclofenac, extractive-spectrophotometric, Voltaren, experimental design.
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Keywords: Diclofenac, extractive-spectrophotometric, Voltaren, experimental design.
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Abstract: A sensitive extractive-spectrophotometric method was developed for the determination of diclofenac. To obtain the optimal extractive-spectrophotometric response for diclofenac, two statistical models were applied: the Box-Behnken experimental design model and the response surface plot. Good agreement with Beer's law was found within the diclofenac concentration range of 0.2-2.0 µg/ml, with a detection limit of 0.02 µg/ml. The method was successfully applied to the determination of diclofenac in various pharmaceutical formulations, yielding satisfactory results.
- Pedro Luis López-de-Alba
- Luis Iván Michelini-Rodríguez
- Luis Manuel Orozco Castellanos
- Ricardo Alberto Rodríguez Carvajal
- Norberto Flores Guzmán
