EVIDENCE ON VITAMIN D SUPPLEMENTATION IN HEALTHY ADULTS: A LITERATURE REVIEW

• DOI: https://doi.org/10.22533/at.ed.1594912414105

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• Abstract:

  Introduction: Vitamin D deficiency or insufficiency is considered a global public health problem due to its implications in the development of various diseases. Historically, rickets was one of the first diseases associated with vitamin D deficiency, the cause of which was only clarified centuries after the first reports. The main source of vitamin D is endogenous synthesis by the skin after exposure to ultraviolet B radiation, while the diet contributes a smaller fraction. Current guidelines indicate screening for vitamin D deficiency only in people at high risk, with supplementation adjusted according to individual needs. Cholecalciferol (vitamin D3) is the most widely used metabolite for supplementation, and is preferred to ergocalciferol (vitamin D2) due to its greater efficacy and longer half-life.