Background: Diabetes Mellitus (DM) is the most common endocrine pathology. Diabetic neuropathy can affect the gastrointestinal tract, leading to dyspepsia and subsequent upper gastrointestinal diseases. Materials and Methods: In this descriptive observational retrospective study, we re- viewed the clinical records and pathology reports of 236 patients who underwent elective upper endoscopy with biopsy throughout the year 2022. Data was analyzed using frequencies, percentages and correlation tests of Spearman and Odds Ratio (OR). Results: We discovered that epigastralgia was the leading presenting symptom that led to endoscopic evaluation in both diabetic and non-diabetic patients. Gastritis was the most frequent finding in both groups (97.5%). Pangastritis was more common in DM (56.8%) and antral gastritis was most common in non-diabetics (66.1%). Esophageal reflux, peptic ulcer disease, and duodenitis was more common in diabetics than in non- diabetics. Over 95% of both groups were positive for H.pylori infection. Conclusions: Diabetes mellitus leads to gastrointestinal complications due to dyspepsia and diabetic neuropathy. It is of great importance that the symptoms and gastrointestinal complications are considered at the time of diagnosis and management of patients with diabetes mellitus. Integrating clinical history, age, endoscopic and histopathological findings.-