EVALUATION OF ANTIMICROBIAL CONSUMPTION IN UNITS OF ADULT INTENSIVE CARE: correlation with bacterial resistance

• DOI: 10.22533/at.ed.1592602211106

• Palavras-chave: Consumption of antimicrobials. set daily dose. Bacterial resistance.

• Keywords: Consumption of antimicrobials. set daily dose. Bacterial resistance.

• Abstract:

  Inappropriate use of antimicrobials can lead to health, economic and social problems in both the short and long term. This is a cross-sectional study, carried out in the adult Intensive Care Units (ICU) of a General Hospital (HG) located in the Salvador Railway Suburb, Bahia, with the objective of evaluating the consumption of antimicrobials correlating with the incidence density of resistant bacteria. from 2014 to 2018. Antimicrobial consumption was obtained through the pharmacy's hospital management system, being evaluated and expressed through the defined daily dose (DDD) per 1000 patient-days. Data for the realization of incidence densities (ID) of resistant bacteria were obtained through the Hospital Infection Control Service (SCIH) system and expressed per 1000 patient-days. In evaluating the results, Acinetobacter baumannii resistant to carbapenems was the most isolated pathogen (6,87 DI ₁₀₀₀), the most consumed antimicrobial was piperacillin/tazobactam (231 DDD 1000) and among the correlations,Klebsiella pneumoniae ceftriaxone resistant and its consumption denoted to be one of the most important (R=0,396 e P=0,002). The study showed a decrease in the consumption of cefepime and teicoplanin and a high consumption of piperacillin/tazobactam and ceftriaxone, as well as a high incidence of some resistant bacteria, emphasizing the need and importance of better control of antimicrobial consumption, and dissemination of resistant strains.