EVALUATION OF CYTOTOXICITY AND GENOTOXICITY OF CHEMICAL MATERIAL IN PM2.5 FILTERS FROM THREE MONITORING STATIONS OF THE AIR QUALITY NETWORK OF THE ABURRÁ VALLEY

• DOI: https://doi.org/10.22533/at.ed.1594742408082

• Palavras-chave: material particulado, viabilidad celular, daño en el ADN, Ensayo Cometa.

• Keywords: particulate matter, cell viability, DNA damage, Comet assay.

• Abstract:

  The increase in air pollution and its adverse effects has raised concerns about regulatory policies and has encouraged the development of new air quality standards. Environmental toxicants can have various effects ranging from irritation to cell and tissue death; however, some genotoxic compounds produce alterations in the genetic material or its associated components, causing mutations or interfering with some repair or polymerization processes involved in chromosome segregation. The objective of this study was to evaluate the effect on the viability and genotoxic potential of PM2.5 particulate matter obtained from filters collected from three monitoring stations of the air quality network in the Aburrá Valley, Colombia, on the CHO-K1 and Jurkat cell lines. The tests carried out revealed a reduction in cell viability and punctual damage to DNA. The results suggest that PM2.5 material has genotoxic potential and can induce cancer development, as has been suggested in other studies.