Study of hypercoagulability in patients with covid-19 and its repercussions

• DOI: https://doi.org/10.22533/at.ed.1594832406094

• Palavras-chave: Venous Thromboembolism; Hospitalization; Coronavirus Infections; Venous Thrombosis; COVID-19.

• Keywords: Venous Thromboembolism; Hospitalization; Coronavirus Infections; Venous Thrombosis; COVID-19.

• Abstract:

  Objective: To verify the potential of D-dimer as a predictor of venous thromboembolism (VTE) in patients hospitalized for COVID-19 and risk factors for elevated D-dimer, for VTE and for evolution to death. Method: The study consisted of a retrospective cohort, which collected data from the electronic medical records of 238 patients over 18 years of age, hospitalized with a diagnosis of COVID-19 registered at the Santa Casa de Misericórdia Hospital in Vitória, in 2020. Absolute and relative frequency distributions were used for statistical analysis, as well as calculating the relative risk (RR) and its confidence interval at the 95% reliability level. The project was approved by Emescam's Research Ethics Committee (CAAE: 47510121.8.0000.5065). Results: Of the 238 patients, 92 were excluded because they did not have confirmation of SARS-CoV-2 infection by RT-PCR recorded in their medical records. It was not possible to calculate the RR of elevated D-dimer related to the occurrence of VTE, making it impossible to analyze the marker. In the other analyses, no associations were found for the outcomes elevated D-dimer, VTE and death, with the exception of prolonged length of hospital stay in relation to VTE (RR: 9.10 / CI: 1.12-73.67) and death (RR: 4.62 / CI: 1.80-11.86). Conclusion: The study did not prove many of the associations documented in the literature, including the relationship between elevated D-dimer and VTE in patients hospitalized for COVID-19. Thus, further studies are needed with larger numbers of patients and occurrences of VTE, allowing the formation of more informed conclusions that improve the management of these patients.