CLINICAL AND MORPHOLOGICAL STUDY OF HEMANGIOSARCOMA IN CANINES (HSC)

• DOI: https://doi.org/10.22533/at.ed.973522527013

• Palavras-chave: immunohistochemistry, metastasis, neoplasia, pathology, tumor.

• Keywords: immunohistochemistry, metastasis, neoplasia, pathology, tumor.

• Abstract:

  Canine hemangiosarcoma (HSC) is a malignant neoplasm of mesenchymal origin that presents as a multicentric disease. The aim of this study was to review the anatomopathological and immunohistochemical findings and clinical results in canine patients who were referred for necropsy and had a histopathological diagnosis of hemangiosarcoma in the veterinary pathology laboratory of the Universidad de La Salle-Bogotá. We reviewed 794 necropsy histories in the period 2010 to 2019; 17 histories were selected; clinical histories of cases that were attended at the small animal clinic of La Salle University were searched. Ki67, c-kit and SOX2 immunomarkers were used. HSC corresponded to 2.1% of mortality; 82% were males; 65% of the cases occurred in canines over 25 kg; the most affected breed was the Golden retriever (29%); the mean age of presentation was 11 years. Fifty-three percent of the patients were euthanized; 76% presented with CAH of visceral origin; the most affected organ was the lung. The most frequent clinical signs were normocytic normochromic anemia, thrombocytopenia and neutrophilic leukocytosis. Fifty-nine percent of patients were stage III, 35% were grade II and 71% were cavernous. Immunohistochemical labeling was moderate with Ki67 and mild with c-kit and SOX2 in 30%, 60% and 50% of cases, respectively. No patient received chemotherapy treatment. Further research is needed in early diagnosis, metastasis and the search for new therapeutic targets