NUTRITIONAL STRATEGIES FOR MODULATION OF THE rs 9939609 POLYMORPHISM OF THE FTO GENE IN THE PREVENTION AND TREATMENT OF OBESITY IN CHILDREN AND ADOLESCENTS

• DOI: https://doi.org/10.22533/at.ed.0159422404013

• Palavras-chave: nutrigenomics; child; teenagers; obesity; "Alpha-Ketoglutarate-Dependent FTO Dioxygenase.

• Keywords: nutrigenomics; child; teenagers; obesity; "Alpha-Ketoglutarate-Dependent FTO Dioxygenase.

• Abstract:

  Goal: Study the nutrigenomic and nutrigenetic aspects involving obesity in children and adolescents, focusing on the rs9939609 polymorphism of the FTO gene, analyze the effects of this genetic variant on body fat gain and address possible nutritional strategies. 

  Methods: This is a bibliographic review carried out in the electronic databases SCIELO, PUBMED, Google Scholar, LILACS, together with academic literature related to the subject, in Portuguese, English and Spanish. The key words were used: "nutrigenomics", "child", "adolescents", "obesity", "FTO Dioxygenase Dependent on Alpha-Ketoglutarate", "nutrigenomics", "adolescent", "child", "childhood", " obesity", "Alpha-Ketoglutarate-Dependent Dioxygenase FTO".

  Results and discussion: The daily value of lipids ingested, the type, especially saturated fatty acids, and the quantity showed an interaction with the rs939609 polymorphism of the FTO gene. In individuals carrying the risk allele (A) and with a higher intake of saturated fatty acids, they had a high BMI compared to homozygotes (TT). Studies regarding carbohydrates and proteins are scarce, hindering a conclusion about them.

  Conclusion: Lower daily intake of lipids and saturated fatty acids may be a possible nutritional strategy for managing the rs9939609 polymorphism in the FTO gene in children and adolescents. However, it is important to monitor future publications that may bring greater clarity and understanding about nutrients and their relationship with rs9939609 of the FTO gene.