THERAPEUTIC EFFICACY OF ISOTRETINOIN IN THE TREATMENT OF ACNE VULGAR: A BIBLIOGRAPHICAL REVIEW

• DOI: https://doi.org/10.22533/at.ed.1594632428069

• Palavras-chave: isotretinoin, acne vulgaris, quality of life, safety, treatment.

• Keywords: isotretinoin, acne vulgaris, quality of life, safety, treatment.

• Abstract:

  Objective: To analyze the therapeutic efficacy of isotretinoin in the treatment of moderate to severe acne, considering its safety and impact on patients' quality of life. Method: Literature review using the PubMed database, with search terms such as "isotretinoin", "moderate to severe acne", "clinical results and quality of life". 31 articles were analyzed. Results: Acne vulgaris is prevalent in puberty and adolescence, with oral isotretinoin being a primary therapeutic option. Recent studies indicate improvements in quality of life, despite adverse effects such as anxiety, depression and suicidal ideation, related to the severity of acne and a history of psychological conditions. There is no therapy with fully proven efficacy. Final considerations: Oral isotretinoin has favorable clinical results and improved self-esteem, but more research is needed to benefit patients with moderate to severe acne.