EFFICACY AND SAFETY OF OVARIAN STEM CELL TRANSPLANTATION IN PATIENTS WITH PRIMARY OVARIAN INSUFFICIENCY AND POOR OVARIAN RESPONSE: A SYSTEMATIC REVIEW

• DOI: 10.22533/at.ed.1593152306038

• Palavras-chave: Female infertility; Primary ovarian insufficiency; Ovarian reserve; Poor responder; Cell therapy; Transplantation; Mesenchymal stem cells.

• Keywords: Female infertility; Primary ovarian insufficiency; Ovarian reserve; Poor responder; Cell therapy; Transplantation; Mesenchymal stem cells.

• Abstract:

  Objective. To perform a systematic review to evaluate the efficacy and safety of mesenchymal stem cell transplantation in the treatment of patients with reduced ovarian function or poor response to infertility treatment.
   Methods. Studies published over the last 10 years (from January 2012 to June 2022) were analyzed by systematic review using the PubMed, Cochrane Library, Scopus and National Library of Medicine (ClinicalTrials.gov) databases as references. Materials and methods included the checklist determined by the PRISMA Statement, 2020. The risk of bias of the studies was inferred by two independent reviewers and evaluated using the Risk of Bias (RoB) 2.0 tool provided by the Cochrane Library. This systematic review was registered in the Prospero platform with the identification number CRD42022354259.
   Results. Fifteen studies that met the selection criteria were within the scope of this review. The analyzed studies involved publications from the last ten years that evaluated ovarian stem cell transplantation in patients with decreased ovarian function or poor ovarian response and were found in the selected databases.
   Conclusion. From this review of the studies that met the inclusion criteria, we can conclude that there is a lack of randomized studies with a high number of patients. Furthermore, it was observed that no study evaluated the safety of the proposed long-term therapy. However, through the analysis of the obtained results, it can be concluded that ovarian stem cell transplantation seems to be promising for this group of patients who, in turn, do not have any established treatment.