Effects of Cannabis in Parkinson's Disease and Other Movement Disorders

• DOI: https://doi.org/10.22533/at.ed.159410424131214

• Palavras-chave: Cannabis; Parkinson's Disease; Cannabinoids; Movement Disorders; Neuroprotection

• Keywords: Cannabis; Parkinson's Disease; Cannabinoids; Movement Disorders; Neuroprotection

• Abstract: INTRODUCTION Cannabis has gained attention as a potential therapeutic agent for Parkinson’s disease and other movement disorders. Research highlights its role in managing motor symptoms such as tremor, rigidity, and bradykinesia, as well as non-motor symptoms like anxiety and sleep disturbances. The pharmacological properties of cannabinoids, including THC and CBD, suggest broad applicability due to their interaction with the endocannabinoid system. However, variability in patient responses and study methodologies has limited consensus on optimal therapeutic approaches. OBJETIVE To evaluate the efficacy, safety, and therapeutic potential of cannabis in the management of Parkinson's disease and other movement disorders, focusing on its impact on motor and non-motor symptoms and its potential neuroprotective effects. METHODS This is a narrative review which included studies in the MEDLINE – PubMed (National Library of Medicine, National Institutes of Health), COCHRANE, EMBASE and Google Scholar databases, using as descriptors: “Cannabinoids in Neurological Disorders” AND “Parkinson's Disease Therapy” OR “Movement Disorders Management” OR “Cannabis and Neuroprotection” OR “Non-Motor Symptom Treatment” in the last 5 years. RESULTS AND DISCUSSION Clinical and preclinical studies indicate that cannabis can mitigate levodopa-induced dyskinesias and improve overall quality of life in patients. Neuroprotective properties, such as reducing oxidative stress and neuroinflammation, have been demonstrated, suggesting potential benefits in slowing disease progression. Despite promising findings, safety concerns, including psychoactive side effects and dosing inconsistencies, underscore the need for further research. CONCLUSION Cannabis offers a novel approach to addressing unmet needs in movement disorder management. By integrating cannabinoids into comprehensive care models and addressing current regulatory and research challenges, cannabis-based therapies could significantly enhance treatment outcomes for these complex neurological conditions.