ENDOCRINOLOGICAL DISORDERS IN DOWN SYNDROME: EVALUATION, TREATMENT AND IMPACT ON QUALITY OF LIFE

• DOI: https://doi.org/10.22533/at.ed.1594524100110

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• Abstract:

  Goal: Comprehensively analyze the main endocrinological changes that occur in Down Syndrome, offering a detailed approach to assessment, treatment and the impact of these changes on quality of life. Methods: Bibliographic review conducted in the PubMed Central database, resulting in 334 articles. Subsequently, after rigorous application of inclusion and exclusion criteria, only 11 articles were selected to be part of the present study. Results: It was observed that among the most recurrent endocrine-metabolic changes in patients with Down Syndrome are hypothyroidism, associated with type 1 diabetes mellitus, with increased risks and prevalence due to specific genetic factors and hormonal dysregulations. Final considerations: The comprehensive review carried out in this article highlights endocrine-metabolic dysfunctions in patients with Down Syndrome, highlighting the importance of an accurate diagnosis to direct necessary therapeutic interventions, ensuring the health and well-being of these individuals.