DEVELOPMENT OF EXTENDED GATE FIELD EFFECT TRANSISTOR (EGFET) FOR QUANTIFICATION OF PHOSPHORUS MASS REMOVED FROM CHRONIC KIDNEY PATIENTS IN HEMODIALYSIS SESSIONS
DEVELOPMENT OF EXTENDED GATE FIELD EFFECT TRANSISTOR (EGFET) FOR QUANTIFICATION OF PHOSPHORUS MASS REMOVED FROM CHRONIC KIDNEY PATIENTS IN HEMODIALYSIS SESSIONS
-
DOI: https://doi.org/10.22533/at.ed.3174262401116
-
Palavras-chave: EGFET, óxido de alumínio, hemodiálise, fosfato, filmes finos.
-
Keywords: EGFET, aluminum oxide, hemodialysis, phosphate, thin films.
-
Abstract: Hemodialysis is a procedure that seeks to remove excess fluids and substances accumulated in the body of patients with kidney failure (chronic kidney disease). Excess substances such as phosphorus are harmful to the body, and the control of its serum level in chronic kidney disease patients during hemodialysis represents a challenge for nephrologists. The elevated level of phosphate in the blood (hyperphosphatemia) is associated with death cases in chronic kidney disease patients. This work presents the development of an extended gate field effect transistor (EGFET) for phosphorus mass quantification in the final total dialysate (FTD) extracted during the hemodialysis process. Initially, an electrolyte-insulating-semiconductor device (EIS) was manufactured to be connected to the gate of a commercial MOSFET to form the EGFET. For the EIS device, thin aluminum oxide films (Al2O3) deposited on a structure composed of a thin layer of silicon oxide (SiO2) on the silicon substrate were used. In addition, a reference electrode was manufactured containing an ion-selective membrane based on poly vinyl alcohol, along with the insertion of an organic compound diethylenetriamine to be used in the EGFET. The results indicated the phosphate concentration in the range of zero to 7 mg/dL in FTD and a sensitivity of 97 mV/(mg/dL), confirming that the EGFET is an innovative solution for real time measurement of phosphate concentration in FTD for the quantification of the phosphorus mass that is removed from the chronic renal patient during the hemodialysis session.
- SERGIO HENRIQUE FERNANDES