COPAIBA OIL-RESIN IMPROVES PONDERAL DEVELOPMENT AND ATTENUATES INFLAMMATION IN ADIPOSE TISSUE IN A MODEL OF HEPATIC CIRRHOSIS

• DOI: 10.22533/at.ed.1592242215051

• Palavras-chave: Liver cirrhosis, inflammation, copaiba oil-resin, adipose tissue.

• Keywords: liver cirrhosis, inflammation, copaiba oil-resin, adipose tissue.

• Abstract:

  The aim of this study was to evaluate the effect of copaiba oil-resin on body weight, adiposity and inflammatory markers in adipose tissue in animals with liver cirrhosis. Male Wistar rats were randomly divided into two groups: Liver Cirrhosis (CH, n=7) and CH + copaiba oil-resin (CH+OC, n=7). Liver cirrhosis was induced by intraperitoneal (i.p.) administration of thioacetamide at a dose of 100mg/kg/twice a week; and copaiba oil-resin supplementation was administered, via gavage, at a dose of 200mg/kg/day for 8 weeks. The data show that copaiba oil-resin supplementation was able to improve weight gain and adiposity in animals with liver cirrhosis, in addition to increasing the levels of IL-10, an anti-inflammatory cytokine, and reducing the levels of IL-10. 1β, pro-inflammatory cytokine. These findings suggest a beneficial effect of copaiba oil-resin on adipose tissue in a liver cirrhosis model.

• Número de páginas: 14