Lipid-Rich Carcinoma of the Breast: A Case Report

• DOI: https://doi.org/10.22533/at.ed.0159652616047

• Palavras-chave: lipid-rich carcinoma; breast cancer; neoadjuvant chemotherapy; complete pathological response; rare histology.

• Keywords: lipid-rich carcinoma; breast cancer; neoadjuvant chemotherapy; complete pathological response; rare histology.

• Abstract:

  Lipid-rich carcinoma of the breast (LRC) is an extremely rare histological variant, accounting for less than 0.001% of breast cancers. It is characterized by tumor cells with abundant, vacuolated cytoplasm rich in neutral lipids, biologically aggressive behavior, and a generally poor prognosis. We report the case of a 53-year-old female patient diagnosed with multicentric LRC of the right breast (T2NXM0), Luminal B subtype, histological grade 2–3, treated with neoadjuvant chemotherapy (AC-DD followed by paclitaxel), achieving a confirmed near-complete pathological response after quadrantectomy with sentinel lymph node biopsy. The patient continued with hormone therapy (letrozole), a CDK4/6 inhibitor (ribociclib), zoledronic acid, and adjuvant radiotherapy. This case stands out due to the rarity of the histology, the unusual multicentric presentation, and the outcome following neoadjuvant therapy, contributing to the understanding of the management of this poorly documented neoplastic entity.