BIOMARKERS ASSOCIATED WITH ACUTE RENAL INJURY IN SEPTIC SHOCK: An integrative literature review

• DOI: https://doi.org/10.22533/at.ed.15951925260411

• Palavras-chave: Acute kidney injury; Septic shock; Biomarkers.

• Keywords: Acute kidney injury; Septic shock; Biomarkers.

• Abstract:

  Introduction: Septic shock is a critical clinical condition that often culminates in significant kidney damage, increasing the risk of mortality. ARF is the result of a complex immune response that causes ATL and compromises renal function. Objectives: To highlight the main biomarkers of stress, damage and function in ARF associated with septic shock. Methodology: The following descriptors "Acute Kidney Injury", "Biomarkers", "Shock Septic" and "Sepsis" were applied to the PubMed, Science Direct, BVS and SciELO databases, selecting original articles published between 2019 and 2024 in the English language. Results: The 12 articles analyzed in this review portrayed various biomarkers, with emphasis on NGAL, useful for early detection of ATL. Analyses involving TIMP 1, TIMP 2, adhesion molecules, MR-proADM were postulated as promising prognostic indicators in the context of ARI. As well as HBP, which proved to be significantly effective in predicting the severity of kidney damage. Conclusion: The application of these biomarkers represents a significant advance in the clinical management of ARF associated with septic shock, improving early diagnosis and enabling more targeted treatments.