Biohacking Longevity: Genomic and Epigenetic Modulation for Personalized Neurofunctional Interventions

• DOI: https://doi.org/10.22533/at.ed.15953125300913

• Palavras-chave: longevity biohacking; neurogenomics; Nrf2 HO-1; PINK1 PRKN; SIRT1 FOXO AMPK; BMAL1; BDNF TrkB.

• Keywords: longevity biohacking; neurogenomics; Nrf2 HO-1; PINK1 PRKN; SIRT1 FOXO AMPK; BMAL1; BDNF TrkB.

• Abstract:

  This paper organizes mechanistic evidence on functional longevity and cognitive preservation, focusing on pathways that connect bioenergetics, redox control, and mitochondrial quality. The SIRT1 FOXO mTOR AMPK axes, the Nrf2 HO-1 antioxidant response, PINK1 PRKN mitophagy, the BMAL1-mediated molecular clock, and the BDNF TrkB synaptic system are discussed. The selected literature describes convergent effects, such as induction of autophagy and mitophagy, modulation of reactive oxygen species, maintenance of endothelial junctions in the blood-brain barrier, support of mitochondrial biogenesis, and support of synaptic plasticity. Based on these mechanisms, the text outlines measures applicable in clinical practice and in a low-risk behavioral context, with objective monitoring and respect for experimental extrapolation limits. The final proposal is a decision roadmap that prioritizes safety, measurability, and individual stratification by integrating genomics, epigenetics, and neuroscience (Bin-Jumah et al., 2022; Loboda et al., 2016; Zhai et al., 2022; Choi et al., 2014; Navarro; Esteras, 2024; Guan; Chen; Dong, 2025; Tang et al., 2025; Sang et al., 2025; Toader et al., 2025; Csik et al., 2025).