ADVANCES IN IMMUNOLOGY AND AUTOIMMUNE DISEASES: NEW INSIGHTS AND THERAPIES IN THE TREATMENT OF AUTOIMMUNE CONDITIONS

• DOI: https://doi.org/10.22533/at.ed.15952925150812

• Palavras-chave: Imunologia. Doença Autoimune. Imuno modulação

• Keywords: Imunologia. Doença Autoimune. Imuno modulação

• Abstract:

  Autoimmune diseases represent a heterogeneous set of more than 80 chronic conditions characterized by an aberrant immune response against self-antigens, resulting in persistent inflammation and tissue damage. Given this, the present study aims to develop a study on the main advances in immunology and autoimmune diseases, identifying new insights and therapies in the treatment of autoimmune conditions. The methodology applied was based on a literature review, using books and scientific articles from databases on the subject, between 2020 and 205. The results identified a broad spectrum of therapeutic modalities, ranging from the most contemporary and disruptive advances in the field, such as metabolic glycoengineering, gene therapies with CAR T cells supported by messenger RNA technology, and the application of mesenchymal stem cells. The synthesis of such evidence provides substantive insights of considerable relevance to clinical practice and scientific research. In conclusion, it should be noted that recent advances reposition the therapeutic goal of not only controlling inflammation but also reprogramming the immune response toward tolerance, preserving defense against infections and neoplasms and reducing the burden of adverse effects. The challenge now is to transform this potential into reproducible, safe, and accessible clinical routines.