EVALUATION OF THE PROMOTER POLYMORPHISM (-G1082A) OF THE INTERLEUKIN 10 (IL-10) GENE IN THE SEVERITY OF UPPER GI HEMORRHAGE

• DOI: 10.22533/at.ed.1593422302062

• Palavras-chave: Schistosomiasis mansoni. Interleukin-10. periportal fibrosis. Genetic polymorphism. High digestive bleeding.

• Keywords: Schistosomiasis mansoni. Interleukin-10. periportal fibrosis. Genetic polymorphism. High digestive bleeding.

• Abstract:

  Introduction: Genotypic variants of the IL-10 gene may participate in the molecular mechanisms of Periportal Fibrosis (PPF) and, possibly, of Upper Digestive Hemorrhage (HDA) in schistosomal patients. Method: This is a cross-sectional study involving 124 individuals infected with Schistosoma mansoni, after specific treatment, to verify the association between the genetic polymorphism (-G1082A) IL-10 and serum concentrations of IL-10 with HDA. Results: There was no evidence of association between the (-G1082A) IL-10 polymorphism and its serum concentrations with HDA. Conclusions: The (-G1082A) IL-10 polymorphism and serum IL-10 levels were not associated with UDH in this population.