Evaluation of the promoter polymorphism (-C819T) of the gene Interleukin-10 (IL-10) in the severity of upper gastrointestinal bleeding
Introduction:Upper gastrointestinal bleeding (HDA) is a serious consequence of schistosomiasis mansoni, resulting from the inflammatory process mediated by IL-10. Method: This is a cross-sectional study involving 123 individuals infected with Schistosoma mansoni, after specific treatment, to verify the association between the genetic polymorphism (-C819T) IL-10 and its serum concentrations with HDA. Results: There was no evidence of an association between the (-C819T) IL-10 polymorphism and its serum concentrations with HDA. Conclusions: The IL-10 (-C819T) polymorphism and levels of IL-10were not associated with HDA in this population.
Evaluation of the promoter polymorphism (-C819T) of the gene Interleukin-10 (IL-10) in the severity of upper gastrointestinal bleeding
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DOI: 10.22533/at.ed.1592782208126
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Palavras-chave: Schistosomiasis mansoni, Interleukin-10, Periportal Fibrosis, Genetic polymorphism.
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Keywords: Schistosomiasis mansoni, Interleukin-10, Periportal Fibrosis, Genetic polymorphism.
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Abstract:
Introduction:Upper gastrointestinal bleeding (HDA) is a serious consequence of schistosomiasis mansoni, resulting from the inflammatory process mediated by IL-10. Method: This is a cross-sectional study involving 123 individuals infected with Schistosoma mansoni, after specific treatment, to verify the association between the genetic polymorphism (-C819T) IL-10 and its serum concentrations with HDA. Results: There was no evidence of an association between the (-C819T) IL-10 polymorphism and its serum concentrations with HDA. Conclusions: The IL-10 (-C819T) polymorphism and levels of IL-10were not associated with HDA in this population.
Keywords: Shistosomiasis mansoni, Interleukin-10, Periportal fibrosis, Genetic polymorphism.
- Taynan da Silva Constantino
- Maria Clara Silva Bezerra
- Bertandrelli Leopoldino de Lima
- Anna Laryssa Mendes de Oliveira
- Thayná da Silva Constatino
- Ana Risoflora Alves de Azevedo
- Aline de Melo Silva.
- Letícia Moura de Vasconcelos
- Jamile Luciana Silva
- Antônio José de Vasconcelos Neto.
- Ana Lúcia Coutinho Domingues
- Prof Dra Paula Carolina Valença Silva.
