EVALUATION OF SLEDAI INFLAMMATORY ACTIVITY IN SYSTEMIC LUPUS ERYTHEMATOSUS IN RELATION TO CHANGES IN THE WHITE AND RED SERIES OF THE BLOOD COUNT

• DOI: https://doi.org/10.22533/at.ed.1595325090112

• Palavras-chave: Lupus, SLEDAI, autoimmune, inflammation.

• Keywords: Lupus, SLEDAI, autoimmune, inflammation.

• Abstract:

  Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune inflammatory disease characterized by an imbalance in the immune system, which causes damage to its own cells, causing damage throughout the body. Symptoms vary from fever, fatigue, joint pain, skin rashes (butterfly wings) to severe kidney, lung and heart damage. The etiology comprises a combination of genetic, hormonal, environmental and infectious factors. The aim of this study is to correlate the inflammatory activity of SLE using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) with alterations in the white and red blood count. This is a retrospective longitudinal study using a repeated measures design, carried out between June 2010 and February 2014 at the General University Hospital (HGU) in Cuiabá-MT. With patients diagnosed with SLE according to the American College of Rheumatology (ACR) criteria, the data was analyzed using Pearson's correlation. There was a significant association between SLEDAI and red series, which showed a decrease in hemoglobin, hematocrit, VCM, HCM and CHCM. In addition, leukopenia, basopenia and lymphopenia were present in proportion to the increase in inflammatory activity, demonstrating a significant drop in immune defense cells. The database of results showed hematological alterations, characterized by microcytic and hypochromic anemia and greater susceptibility to infections due to the drop in the white series, positively correlating hematological alterations with the inflammatory activity of the disease and the action of autoantibodies. Therefore, the monitoring of patients with SLE must take into account these complex interactions between the disease and the hematological system, directing treatment strategies that are increasingly effective in controlling the disease and preventing damage to health.