ASSOCIATION OF HELICOBACTER PYLORI WITH THE LEWIS ANTIGEN: A LITERATURE REVIEW

• DOI: 10.22533/at.ed.1593962321111

• Palavras-chave: Blood Group, Helicobacter pylori, Lewis antigen

• Keywords: Blood Group, Helicobacter pylori, Lewis antigen

• Abstract:

  Since the 90s, several studies have presented the probable relationship between antigens of the ABO-Lewis system and susceptibility to infections, as they end up serving as receptors or co-receptors for these microorganisms. This literary review study aimed to demonstrate the correlation between the pathogenesis of infection by Helicobacter pylori and the Lewis blood system, in order to spread knowledge of the importance of blood phenotypes to health professionals. Data collection was carried out using the PubMed and SciELO reference bases over a period of 20 years (2002 - 2022) with the terms "Blood type", "Lewis system", "ABO system'', "H. Pylori", “Helicobacter pylori.” Helicobacter pylori binds to the antigen Lewis b (Le b), rich in fucose and expressed on the surface of gastric epithelial cells. Furthermore, Le b has high affinity for BabA adhesins, one of the virulence factors of this genus of bacteria that infect humans and promote chronic inflammation and/or other gastric diseases. Since infection by this microorganism is characterized by chronicity, knowledge of its pathogenesis and correlation with all types of risk factors is an important prevention mechanism.