CLINICAL ASPECTS OF INTER VIVOS LIVER TRANSPLANTATION AND ITS IMPACT ON WAITING LIST AND POST-TRANSPLANT RESULTS
Introduction: Living-associated liver transplantation (LIT) consists of transplanting a portion of the liver from a healthy donor to a sick recipient, representing a possible treatment for terminal liver disease. Both the allograft in the recipient and the remaining liver from the donor will regenerate, proving to be a possible approach to mitigate organ shortages. Objective: To understand the clinical aspects of LIT, considering the possible impact on the waiting list and post-transplant outcomes. Method: This is a bibliographic review of the Pubmed and Scielo databases, using the search strategy "Liver Transplantation” AND "Living Donors". The inclusion criteria in the first platform were studies published in the last year (in Portuguese and English) and available as full texts. The selection of articles was made in a staggered manner, by title, abstract and full text, including 8 articles. Results: Studies have shown that THI reduces the waiting time on the transplant list, allows surgery planning so that patients are stable and allows a graft with minimal ischemia time. In addition, THI offers an opportunity for recipients with a lower model of end-stage liver disease (MELD) compared to other patients to also be included. It is also an alternative to circumvent the shortage of organs. However, THI encounters ethical barriers, since it involves surgery on a living and healthy individual. There are also disadvantages regarding the receipt of a smaller graft and the higher rate of surgical complications for both the recipient and the donor. Conclusion: THI offers significant benefits to patients on the transplant list and its success depends on the availability of volunteer donors and their willingness to undergo surgery.
CLINICAL ASPECTS OF INTER VIVOS LIVER TRANSPLANTATION AND ITS IMPACT ON WAITING LIST AND POST-TRANSPLANT RESULTS
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DOI: https://doi.org/10.22533/at.ed.1594782419088
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Palavras-chave: Liver transplantation. Living donors. Organ transplantation.
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Keywords: Liver transplantation. Living donors. Organ transplantation.
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Abstract: Introduction: Living-associated liver transplantation (LIT) consists of transplanting a portion of the liver from a healthy donor to a sick recipient, representing a possible treatment for terminal liver disease. Both the allograft in the recipient and the remaining liver from the donor will regenerate, proving to be a possible approach to mitigate organ shortages. Objective: To understand the clinical aspects of LIT, considering the possible impact on the waiting list and post-transplant outcomes. Method: This is a bibliographic review of the Pubmed and Scielo databases, using the search strategy "Liver Transplantation” AND "Living Donors". The inclusion criteria in the first platform were studies published in the last year (in Portuguese and English) and available as full texts. The selection of articles was made in a staggered manner, by title, abstract and full text, including 8 articles. Results: Studies have shown that THI reduces the waiting time on the transplant list, allows surgery planning so that patients are stable and allows a graft with minimal ischemia time. In addition, THI offers an opportunity for recipients with a lower model of end-stage liver disease (MELD) compared to other patients to also be included. It is also an alternative to circumvent the shortage of organs. However, THI encounters ethical barriers, since it involves surgery on a living and healthy individual. There are also disadvantages regarding the receipt of a smaller graft and the higher rate of surgical complications for both the recipient and the donor. Conclusion: THI offers significant benefits to patients on the transplant list and its success depends on the availability of volunteer donors and their willingness to undergo surgery.
- Eduarda Tumoli Ferreira
- Eduarda Endlich de Freitas
- Júlia Seidel Caetano
- Luca Schmitd de Oliveira
- Fernando Henrique Rabelo Abreu dos Santos
