CDH13 GENE WITH CERVICOVAGINAL INFECTIONS IN USERS OF A FAMILY CARE CLINIC IN NORTHERN MEXICO

• DOI: 10.22533/at.ed.813372328078

• Palavras-chave: infecciones del sistema genital, cadherina, cultivo cervical

• Keywords: infections of the genital system, cadherin, cervical culture.

• Abstract:

  Cervicovaginal infections (CVID) are considered the main cause of consultation in primary care, the literature indicates that they have a genetic predisposition component as a relevant susceptibility factor. Infections can occur due to various alterations in the organism, among which adhesion molecules such as cadherins may be involved, which play a fundamental role in a wide range of biological processes. Cadherins are a large group of calcium-dependent adhesion molecules, including cadherin 13, which is involved in intracellular signaling processes, as well as cell-cell adhesion. The gene that encodes this protein, CDH13, has a polymorphism (rs11649622) which leads to a substitution point mutation, in which the ancestral guanine (G) allele is replaced by an adenine (A), this leads to a variation in intronic region 7-8 of this gene. The objective of this study was to study the presence of the rs11649622 polymorphism of the CDH13 gene and its relationship with the presence of CVD in users of the Family Care Clinic of Durango, Mexico. The presence of CVID was determined by vaginal culture, 206 participants were recruited after signing an informed consent; the RT-PCR method was used for the genotyping of the rs11649622 polymorphism of the CDH13 gene using Taqman probes (Thermo Fisher Scientific). Of the recruited patients, 95 presented ICV, which represents a prevalence of 46.1% of infection; the most common was vaginosis caused by Gardnerella vaginalis with a frequency of 65 patients (68.4% of the women with CVID and 31.5% of the total sample). In conclusion, the rs11649622 polymorphism of the CDH13 gene was not associated with the presence of cervicovaginal infections.