The consequences of depression in Alzheimer's: A Literature Review

• DOI: 10.22533/at.ed.1592772202123

• Palavras-chave: Alzheimer's Disease, Depression, Mental Health, Cognitive Dysfunction, Dementia

• Keywords: Alzheimer's Disease, Depression, Mental Health, Cognitive Dysfunction, Dementia

• Abstract:

  Introduction: Alzheimer's disease (AD) is a neurodegenerative pathology of the central nervous system. In addition to cognitive disorders, depression stands out, which is another frequent aspect of dementia, causing anguish and reducing quality of life. Objective: identify the signs of depression in patients with Alzheimer's disease, its pathophysiology, and dementia in individuals who have depression in association with cognitive changes, whether these are reversible or not. Material and methods: A bibliographic review of the scientific literature was carried out, with searches in the Pubmed, Scielo, Google Scholar, Virtual Health Library databases. For this, five descriptors were validated on the DeCs/MeSH descriptors platform, namely: "Alzheimer's Disease", "Depression", "Mental Health", "Cognitive Dysfunction" and "Dementia". Subsequently, the descriptors inserted in the databases for searching for articles. The following inclusion criteria were used: period from 2018 to 2022, publications in Portuguese and English, articles and free magazines Results: 122 articles were found in Bireme, 111 in Pubmed, 247 in Google Scholar and no documents in Scielo, totaling 480 articles, which after the criteria were reduced to 15 (13 from Pubmed and 2 from Google Scholar), which were used to the making of this review. Discussion/Conclusion: The bibliographic survey showed evidence that depression can be an aggravating factor for AD due to the overlapping of significant symptoms between both pathologies.