APPLICATIONS OF BOTULINUM TOXIN BEYOND THE FIELD OF COSMETICS, WITH AN EMPHASIS ON ITS THERAPEUTIC USES

• DOI: https://doi.org/10.22533/at.ed.515721326240612

• Palavras-chave: Botulinum Toxins; Therapeutic Use; Muscle Spasticity; Hyperhidrosis; Bruxism.

• Keywords: Botulinum Toxins; Therapeutic Use; Muscle Spasticity; Hyperhidrosis; Bruxism.

• Abstract:

  Botulinum toxin type A, produced by the bacterium Clostridium botulinum, is notable not only for its aesthetic applications but also for its therapeutic relevance in various areas of healthcare. The objective of this study was to analyze the main therapeutic applications of botulinum toxin, focusing on its mechanisms of action, clinical indications, benefits, and limitations. This is a literature review based on an analysis of scientific publications available in national and international databases. The literature shows that botulinum toxin acts by blocking the release of acetylcholine at the neuromuscular junction, promoting temporary muscle relaxation and effects related to the modulation of pain and glandular activity. Among the main therapeutic indications are the treatment of spasticity, dystonias, chronic migraine, hyperhidrosis, and bruxism, with favorable results in reducing symptoms and improving patients’ quality of life. Despite its demonstrat y efficacy, factors such as the need for periodic re-injections, the limited duration of effects, and variable response among individuals must be considered. The analyzed evidence reinforces the importance of botulinum toxin as a therapeutic option for various clinical conditions, provided its use is safe, judicious, and grounded in scientific