Neural Architecture of Obesity: Interfaces between Genetics, Behavior, and Neuroscience in Supporting Weight Loss

• DOI: https://doi.org/10.22533/at.ed.1595292515086

• Palavras-chave: obesity, neuroscience, eating behavior, genetics, precision medicine, neuroplasticity, DWRI.

• Keywords: obesity, neuroscience, eating behavior, genetics, precision medicine, neuroplasticity, DWRI.

• Abstract:

  This article reviews the complex interaction between neuroscience, behavior, and genetics in the etiology and treatment of obesity, highlighting the limitations of traditional metabolic models. It presents the Deep Wide-ranging Intellectual Interference (DWRI) model, which integrates genetic, neurobiological, and cognitive-behavioral factors to explain dysfunctional eating patterns. The review emphasizes the role of neuroplasticity and precision medicine in the development of individualized and sustainable therapeutic interventions. Techniques such as brain stimulation and cognitive therapies are discussed as promising tools for restructuring the neural circuits involved in food control. The article concludes that multidisciplinary and personalized approaches are essential for advances in the clinical management of obesity.