IMPROVING THE DIAGNOSIS AND TREATMENT OF GESTATIONAL TROPHOBLASTIC DISEASE: CHALLENGES AND PERSPECTIVES

• DOI: https://doi.org/10.22533/at.ed.1594602426068

• Palavras-chave: gestational Trophoblastic Disease; Early diagnosis; DTG treatment.

• Keywords: gestational Trophoblastic Disease; Early diagnosis; DTG treatment.

• Abstract:

  Goal: Investigate gestational complications associated with Gestational Trophoblastic Disease (GTD), as well as explore effective diagnostic, therapeutic and preventive strategies. Method: A bibliographic review was carried out using the PubMed - MEDLINE database. 42 articles were initially identified, of which12were selected based on strict inclusion and exclusion criteria. The inclusion criteria covered articles published between 2014 and 2024 that dealt with topics related to DTG. Duplicate articles, publications only in summary format, and works that did not directly address the topic investigated or that did not meet other inclusion criteria were excluded. Result: The analysis concluded that the beta-HCG test is recommended as an initial diagnostic method due to its simplicity and cost-effectiveness. Early diagnosis proved to be crucial for the clinical improvement of patients, allowing early therapeutic interventions. However, despite not reducing the incidence of subsequent gestational trophoblastic neoplasia (GTN), early diagnosis is associated with a better prognosis when neoplastic complications arise. Final considerations: Continuous training of healthcare professionals is essential to implement these evidence-based practices, thereby improving the quality of care and outcomes for patients affected by GTD.