ANTIOXIDANT AND ANTICANCER EFFECT OF QUERCETIN IN THE PREVENTION AND REPAIR OF CANCEL CELLS

• DOI: 10.22533/at.ed.1592192208043

• Palavras-chave: Quercetin, Cancer, Apoptosis, Autophagy, Antioxidant, Anticancer, Cancer Cells, Necroptosis.

• Keywords: Quercetin, Cancer, Apoptosis, Autophagy, Antioxidant, Anticancer, Cancer Cells, Necroptosis.

• Abstract:

  Quercetin is the main flavonoid in the human diet and has been studied for a few decades. Found in fruits, vegetables and beverages, it is a very effective compound in protecting cells and other molecules mainly through the capture of reactive oxygen species (ROS). It is a molecule with antioxidant, anti-inflammatory and anticancer functions, its action is not only in the protection of healthy cells, but also in the repair or destruction of tumor cells through several mechanisms and different pathways, such as: apoptosis, blocking anti-apoptotic proteins and releasing pro-apoptotic proteins, Necroptosis can also be regulated in a controlled manner through defined signal transduction pathways causing severe damage to tumor cells and destroying them by necrosis, it also promotes an increase in autophagy stimulating a greater cycling of nutrients in the cell, blocking tumor cell multiplication and inhibiting tumor cell angiogenesis, blocking the channel for the advancement of metastasis. Studying and researching the action of quercetin on various cancer cell lines and their metabolic pathways of action in the numerous functions performed by this molecule is fundamental in research for anticancer treatment. 

• Número de páginas: 18