AVENANTHRAMIDE-C, THE MAIN OAT POLYPHENOL, HAS ANTIOXIDANT AND ANTIHEMOLYTIC PROPERTIES

• DOI: https://doi.org/10.22533/at.ed.159512503019

• Palavras-chave: antioxidant, avenanthramide C, oat, reactive oxygen species, ROS.

• Keywords: antioxidant, avenanthramide C, oat, reactive oxygen species, ROS.

• Abstract:

  Free radicals are molecules with unpaired electrons and very unstable, which have the ability to interact with other compounds to transform them into reactive species. One of these molecules are reactive oxygen species (ROS), which have been directly involved in the generation of oxidative stress, characterized by a high production of ROS and by different antioxidant mechanisms in the organism. ROS have the capacity to react with different biomolecules such as lipids, proteins and nucleic acids, being the polyunsaturated fatty acids (PUFA) of cell membranes one of the most important targets of ROS. For this reason, the use of compounds capable of capturing ROS or of positively modulating the activity of the cell's antioxidant mechanisms has become an attractive strategy. Among these compounds are polyphenols, flavonoids and carotenoids present in natural products of plant origin. In this work, the antioxidant effect and potential protective action of avenanthramide C, a polyphenolic compound present in oat grain, on erythrocyte hemolysis induced by exogenous hydrogen peroxide (H2O2) was analyzed. Avenanthramide C showed more effective antioxidant properties than curcumin (polyphenol from Curcuma longa) in addition to a greater protective effect erythrocyte hemolysis.