IMMUNOMODULATORY APPROACHES IN RECURRENT IMPLANTATION FAILURE (RIF): REVIEW OF CLINICAL AND THERAPEUTIC EVIDENCE

• DOI: https://doi.org/10.22533/at.ed.515742512128

• Palavras-chave: Recurrent Implantation Failure, Immunotherapy, Intravenous Immunoglobulin, Intralipids, Assisted Reproduction.

• Keywords: Recurrent Implantation Failure, Immunotherapy, Intravenous Immunoglobulin, Intralipids, Assisted Reproduction.

• Abstract:

  Recurrent implantation failure (RIF) represents one of the main challenges in contemporary reproductive medicine, especially in cases where immunological factors interfere with endometrial receptivity and the establishment of pregnancy. Among the most investigated therapies are intravenous immunoglobulin (IVIG) and intralipids, which act by modulating the maternal immune response, particularly in patients with alterations in the profile of natural killer (NK) cells and inflammatory cytokines. This study aimed to analyze the main immunomodulatory approaches used in RIF, with an emphasis on the efficacy and safety of IVIG and intralipids in assisted reproduction protocols. To this end, an integrative literature review was conducted between February and May 2025, searching the PubMed and SciELO databases, including articles in English that addressed the immunological mechanisms and clinical outcomes of these therapies. The findings show that both IVIG and intralipids can favor implantation and live birth rates in subgroups of patients with specific immunological profiles. However, the lack of standardization in diagnostic criteria and therapeutic protocols limits the generalization of results. It should be noted that advances in reproductive immunology and the integration of professionals, such as biomedical scientists, are fundamental for the development of personalized strategies based on scientific evidence. It is concluded that the careful application of immunomodulatory therapies, combined with prior immunological evaluation and multidisciplinary action, is a promising way to optimize results in reproductive medicine and promote ethical and safe conduct in clinical practice.